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An Open-label, Phase II, Two-stage, Study of Bisantrene(Xantrene) in Combination With Fludarabine and Clofarabine as Salvage Therapy for Adult Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Trial Profile

An Open-label, Phase II, Two-stage, Study of Bisantrene(Xantrene) in Combination With Fludarabine and Clofarabine as Salvage Therapy for Adult Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 22 Jan 2024

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At a glance

  • Drugs Bisantrene (Primary) ; Clofarabine (Primary) ; Fludarabine (Primary)
  • Indications Acute myeloid leukaemia
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 12 Dec 2023 Results assessing the safety and provide phase 2 dose (RP2D, 4 vs 5 days) of infusion (i.v.) with up to 12 pts and an expansion phase with up to 17 pts (Simon 2-stage design 9+8) to assess the primary efficacy and confirm the safety of f Bis/Clo/Flu combination pts with Rel/PR AML were presented at the 65th American Society of Hematology Annual Meeting and Exposition.
  • 10 Aug 2021 New trial record

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