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Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Pediatric Neuroblastoma: A Single-arm, Phase I/II???Multi-center, Clinical Study

Trial Profile

Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Pediatric Neuroblastoma: A Single-arm, Phase I/II???Multi-center, Clinical Study

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 22 Apr 2025

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At a glance

  • Drugs Irinotecan (Primary) ; Rivoceranib (Primary) ; Temozolomide (Primary)
  • Indications Neuroblastoma
  • Focus Therapeutic Use

Most Recent Events

  • 17 Apr 2025 The protocol has been amended to addition in number of arms, interventional study model as sequential assignment and study phase.
  • 17 Apr 2025 Planned number of patients changed from 62 to 125.
  • 19 Sep 2023 Planned End Date changed from 30 Aug 2023 to 30 Dec 2025.

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