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A Phase 2, Open-Label, Multicenter Study of the Combination of RMC-4630 and Sotorasib for Non-Small Cell Lung Cancer Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

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Trial Profile

A Phase 2, Open-Label, Multicenter Study of the Combination of RMC-4630 and Sotorasib for Non-Small Cell Lung Cancer Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 29 Apr 2025

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At a glance

  • Drugs Sotorasib (Primary) ; Vociprotafib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Sponsors REVOLUTION Medicines

Most Recent Events

  • 24 Apr 2025 Status changed from active, no longer recruiting to completed.
  • 19 Apr 2024 This trial has been completed in Germany, according to European Clinical trials database record.
  • 08 Aug 2023 According to a REVOLUTION Medicines media release, company no longer plans to share topline data from the RMC-4630-03 study prior to disclosing decisions about future development of the compound.

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