Trial Profile

A Phase III, Multicentre, Randomised, Double-blind, Placebo-controlled Study to Investigate the Efficacy, Safety, and Tolerability of COMP360 in Participants With Treatment-resistant Depression

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 27 Jun 2025

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At a glance

Drugs Psilocybin (Primary)
Indications Depression; Major depressive disorder
Focus Registrational; Therapeutic Use
Acronyms COMP005
Sponsors COMPASS Pathways

Most Recent Events

23 Jun 2025 Primary endpoint(COMP360 25 mg versus placebo for the change from baseline in MADRS total score) has been met.
23 Jun 2025 Results presented in the COMPASS Pathways media release.
09 May 2025 Planned End Date changed from 1 Feb 2026 to 1 Apr 2026.

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