Trial Profile

A Phase III, Double-blind, Placebo-controlled, Randomised, Multicentre, International Study of Durvalumab Plus Oleclumab and Durvalumab Plus Monalizumab in Patients With Locally Advanced (Stage III), Unresectable Non-small Cell Lung Cancer (NSCLC) Who Have Not Progressed Following Definitive, Platinum-Based Concurrent Chemoradiation Therapy

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 06 Aug 2025

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At a glance

Drugs Durvalumab (Primary) ; Monalizumab (Primary) ; Monalizumab (Primary) ; Oleclumab (Primary)
Indications Non-small cell lung cancer
Focus Registrational; Therapeutic Use
Acronyms PACIFIC-9
Sponsors AstraZeneca; AstraZeneca AB

23 Jul 2025 Planned End Date changed from 31 May 2030 to 2 Jul 2030.
23 Jul 2025 Planned primary completion date changed from 29 May 2026 to 30 Jun 2026.
23 Jul 2025 Status changed from recruiting to active, no longer recruiting.

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