Trial Profile

International Proof of Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory HEMatological Malignancies in Children, Subprotocol D: Trametinib + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 08 Oct 2025

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At a glance

Drugs Cyclophosphamide (Primary) ; Cytarabine (Primary) ; Dexamethasone (Primary) ; Trametinib (Primary) ; Trametinib (Primary)
Indications Haematological malignancies; Precursor cell lymphoblastic leukaemia-lymphoma; Precursor T-cell lymphoblastic leukaemia-lymphoma
Focus Adverse reactions; Proof of concept; Therapeutic Use
Acronyms HEM-iSMART Subprotocol D

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