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A Seamless Phase 1/2 Study to Evaluate the Safety and Efficacy of A2B694, an Autologous Logic-gated Tmod™ CAR T, in Heterozygous HLA-A*02 Adults with Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

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Trial Profile

A Seamless Phase 1/2 Study to Evaluate the Safety and Efficacy of A2B694, an Autologous Logic-gated Tmod™ CAR T, in Heterozygous HLA-A*02 Adults with Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 04 Jun 2025

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At a glance

  • Drugs A2B-694 (Primary)
  • Indications Colorectal cancer; Mesothelioma; Neuroendocrine carcinoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms EVEREST-2
  • Sponsors A2 Biotherapeutics

Most Recent Events

  • 30 Apr 2025 Trial design presented at the 116th Annual Meeting of the American Association for Cancer Research
  • 25 Jan 2025 Trial design presented at the 2025 Gastrointestinal Cancers Symposium.
  • 09 Nov 2024 According to an A2 Biotheraeutics media release, company presented enrollment update on EVEREST-2 study during the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) taking place November 8-10, 2024.

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