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A Randomized, Open-Label, Multicenter Phase III Clinical Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab as First-Line Treatment for PD-L1 Positive Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

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Trial Profile

A Randomized, Open-Label, Multicenter Phase III Clinical Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab as First-Line Treatment for PD-L1 Positive Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 17 Jul 2026

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At a glance

  • Drugs Sacituzumab tirumotecan (Primary) ; Pembrolizumab
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms OptiTROP-Lung05
  • Sponsors Sichuan Kelun Pharmaceutical Research Institute

Most Recent Events

  • 14 Jul 2026 Primary endpoint has been met. (Progression Free Survival (PFS) assessed by Blinded Independent Central Review (BICR)), a Sichuan Kelun-Biotech Biopharmaceutical Media Release.
  • 31 May 2026 Interim results presented in a Sichuan Kelun-Biotech Biopharmaceutical Media Release.
  • 29 May 2026 According to a Sichuan Kelun-Biotech Biopharmaceutical media release, interim data from this study was presented at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago and simultaneously in The Lancet.

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