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ENHANCE (Elevated NKG2A and HLA-E Amplify NK/CD8 Checkpoint Engagers): A Phase 2 Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer

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Trial Profile

ENHANCE (Elevated NKG2A and HLA-E Amplify NK/CD8 Checkpoint Engagers): A Phase 2 Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 06 May 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Monalizumab (Primary)
  • Indications Adenocarcinoma; Bladder cancer; Squamous cell cancer; Urogenital cancer
  • Focus Therapeutic Use
  • Acronyms ENHANCE

Most Recent Events

  • 20 Feb 2025 Planned initiation date changed from 1 Jan 2025 to 1 Mar 2025.
  • 12 Dec 2024 Planned initiation date changed from 1 Dec 2024 to 1 Jan 2025.
  • 12 Dec 2024 Status changed from not yet recruiting to recruiting.

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