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A Phase 2 Open-label Study to Evaluate Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Primary or Secondary Myelofibrosis

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Trial Profile

A Phase 2 Open-label Study to Evaluate Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Primary or Secondary Myelofibrosis

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 Sep 2026

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At a glance

  • Drugs Luspatercept (Primary) ; Momelotinib (Primary)
  • Indications Myelofibrosis
  • Focus Therapeutic Use
  • Acronyms ODYSSEY
  • Sponsors GlaxoSmithKline Research & Development; GSK

Most Recent Events

  • 20 Apr 2026 Planned number of patients changed from 73 to 68.
  • 20 Apr 2026 Planned End Date changed from 13 Nov 2026 to 17 Mar 2028.
  • 20 Apr 2026 Planned primary completion date changed from 14 Oct 2026 to 19 Mar 2027.

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