Trial Profile

A Two-Part, Phase 1/2a Trial to Determine the Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) Obisbemeda (Rhenium-186 NanoLiposome, 186RNL) Delivered Via Convection Enhanced Delivery (CED) in Supratentorial Recurrent, Refractory, or Progressive Pediatric Ependymoma and High-Grade Glioma (HGG)

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 15 Sep 2026

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At a glance

Drugs Rhenium (186Re) obisbemeda (Primary)
Indications Brain cancer; Glioma; Meningeal carcinomatosis; Peritoneal cancer; Squamous cell cancer
Focus Adverse reactions; Therapeutic Use

09 Sep 2026 Planned End Date changed from 1 Mar 2027 to 1 Mar 2028.
09 Sep 2026 Planned primary completion date changed from 1 Mar 2027 to 1 Mar 2028.
09 Sep 2026 Status changed from not yet recruiting to recruiting.

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