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A Phase 2 Single-site, Double-blind, Placebo-controlled, Randomized Clinical Trial With an Open-label Extension Phase to Examine the Safety, Subjective Experiences, Acute Effects, and Suitability of Psilocybin Combined With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD)

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Trial Profile

A Phase 2 Single-site, Double-blind, Placebo-controlled, Randomized Clinical Trial With an Open-label Extension Phase to Examine the Safety, Subjective Experiences, Acute Effects, and Suitability of Psilocybin Combined With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 18 Aug 2026

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At a glance

  • Drugs Psilocybin (Primary) ; Maltodextrin
  • Indications Alcoholism; Post-traumatic stress disorders
  • Focus Adverse reactions
  • Acronyms Psi-PS; Psi-PS

Most Recent Events

  • 13 Aug 2026 Planned End Date changed from 1 Jun 2026 to 1 Jun 2027.
  • 13 Aug 2026 Planned primary completion date changed from 1 Jun 2026 to 1 Nov 2026.
  • 13 Aug 2026 Status changed from recruiting to active, no longer recruiting.

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