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A Phase III Randomized, Open-Label, Multi-Center, Global Study of MEDI4736 in Combination With Tremelimumab Therapy or MEDI4736 Monotherapy Versus Standard of Care Platinum-Based Chemotherapy in First Line Treatment of Patients With Advanced or Metastatic Non Small-Cell Lung Cancer (NSCLC)(MYSTIC)

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Trial Profile

A Phase III Randomized, Open-Label, Multi-Center, Global Study of MEDI4736 in Combination With Tremelimumab Therapy or MEDI4736 Monotherapy Versus Standard of Care Platinum-Based Chemotherapy in First Line Treatment of Patients With Advanced or Metastatic Non Small-Cell Lung Cancer (NSCLC)(MYSTIC)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 10 Mar 2026

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary) ; Carboplatin; Cisplatin; Gemcitabine; Paclitaxel; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms MYSTIC
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 02 Mar 2026 Planned End Date changed from 31 Dec 2025 to 31 Dec 2026.
  • 16 Jan 2025 Planned End Date changed from 31 Dec 2024 to 31 Dec 2025.
  • 16 Jan 2024 Planned End Date changed from 29 Jun 2023 to 31 Dec 2024.

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