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A Phase III Randomized, Open-Label, Multi-Center, Global Study of MEDI4736 in Combination With Tremelimumab Therapy or MEDI4736 Monotherapy Versus Standard of Care Platinum-Based Chemotherapy in First Line Treatment of Patients With Advanced or Metastatic Non Small-Cell Lung Cancer (NSCLC)(MYSTIC).

Trial Profile

A Phase III Randomized, Open-Label, Multi-Center, Global Study of MEDI4736 in Combination With Tremelimumab Therapy or MEDI4736 Monotherapy Versus Standard of Care Platinum-Based Chemotherapy in First Line Treatment of Patients With Advanced or Metastatic Non Small-Cell Lung Cancer (NSCLC)(MYSTIC).

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 23 Jan 2024

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary) ; Carboplatin; Cisplatin; Gemcitabine; Paclitaxel; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms MYSTIC
  • Sponsors AstraZeneca; AstraZeneca AB
  • Most Recent Events

    • 16 Jan 2024 Planned End Date changed from 29 Jun 2023 to 31 Dec 2024.
    • 19 Apr 2023 Results assessing the impact of clonal hematopoietic on molecular response measurement, presented at the 114th Annual Meeting of the American Association for Cancer Research.
    • 04 Jan 2023 Planned End Date changed from 30 Dec 2022 to 29 Jun 2023.
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