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A Phase III, Randomized, Multi-Center, Open-Label, Comparative Global Study to Determine the Efficacy of Durvalumab or Durvalumab and Tremelimumab in Combination With Platinum-Based Chemotherapy for First-Line Treatment in Patients With Metastatic Non Small-Cell Lung Cancer (NSCLC) (POSEIDON)

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Trial Profile

A Phase III, Randomized, Multi-Center, Open-Label, Comparative Global Study to Determine the Efficacy of Durvalumab or Durvalumab and Tremelimumab in Combination With Platinum-Based Chemotherapy for First-Line Treatment in Patients With Metastatic Non Small-Cell Lung Cancer (NSCLC) (POSEIDON)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 10 Oct 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary) ; Carboplatin; Cisplatin; Gemcitabine; Paclitaxel; Pemetrexed
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms POSEIDON
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 30 Apr 2025 Results (n=369) assessing the ability of volumetric radiographic data to more comprehensively assess the impact of anti-CTLA-4 treatment on tumor growth were presented at the 116th Annual Meeting of the American Association for Cancer Research.
  • 06 Jan 2025 Planned End Date changed from 31 Dec 2026 to 15 Nov 2027.
  • 14 Sep 2024 According to a SOPHiA GENETICS media release, retrospective, multimodal analysis of the POSEIDON Phase 3 clinical trial will be presented as a poster by Ferdinandos Skoulidis, Department of Thoracic Medical Oncology, University of Texas MD Anderson Cancer Center at ESMO 2024 hosted in Barcelona, Spain from September 13-17, 2024.

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