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A Multicentre Feasibility Randomized Study of Anti-PD-L1 Durvalumab (MEDI4736) With or Without Anti-CTLA-4 Tremelimumab in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Adenocarcinoma, Treated With a First-line Neo-adjuvant Strategy

Trial Profile

A Multicentre Feasibility Randomized Study of Anti-PD-L1 Durvalumab (MEDI4736) With or Without Anti-CTLA-4 Tremelimumab in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Adenocarcinoma, Treated With a First-line Neo-adjuvant Strategy

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 02 Aug 2023

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary) ; Carboplatin; Paclitaxel
  • Indications Adenocarcinoma; Carcinoma; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Focus Adverse reactions
  • Acronyms INeOV
  • Sponsors ARCAGY/GINECO Group
  • Most Recent Events

    • 28 Jul 2023 Planned End Date changed from 30 Apr 2023 to 28 Feb 2024.
    • 28 Jul 2023 Planned primary completion date changed from 30 Apr 2023 to 28 Feb 2024.
    • 06 Jun 2023 Results assessing good pathological response to NACT +D+/-T is associated with high levels of both T cells and macrophages in iTME at baseline, and increased intratumoral T cell infiltration post-treatment, presented at the 59th Annual Meeting of the American Society of Clinical Oncology
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