Trial Profile

A Phase III Randomized, Open-Label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab in Combination With Tremelimumab and Enfortumab Vedotin or Durvalumab in Combination With Enfortumab Vedotin for Perioperative Treatment in Patients Ineligible for Cisplatin or Who Refuse Cisplatin Undergoing Radical Cystectomy for Muscle Invasive Bladder Cancer (VOLGA)

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 25 Jul 2025

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At a glance

Drugs Durvalumab (Primary) ; Enfortumab vedotin (Primary) ; Tremelimumab (Primary)
Indications Bladder cancer; Urogenital cancer
Focus Adverse reactions; Registrational; Therapeutic Use
Acronyms VOLGA
Sponsors AstraZeneca; AstraZeneca AB

29 Jan 2025 Status changed from recruiting to active, no longer recruiting.
02 Aug 2024 Planned number of patients changed from 830 to 677.
05 Jan 2023 The study has been restarted in Italy, According to European Clinical Trials Database record.

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