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Molecular Analysis for Therapy Choice (MATCH)

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Trial Profile

Molecular Analysis for Therapy Choice (MATCH)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 03 Mar 2025

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At a glance

  • Drugs ABSK 091 (Primary) ; Adavosertib (Primary) ; Afatinib (Primary) ; Binimetinib (Primary) ; Capivasertib (Primary) ; Copanlisib (Primary) ; Crizotinib (Primary) ; Dabrafenib (Primary) ; Dasatinib (Primary) ; Defactinib (Primary) ; Erdafitinib (Primary) ; GSK 2636771 (Primary) ; Ipatasertib (Primary) ; Larotrectinib (Primary) ; Nivolumab (Primary) ; Osimertinib (Primary) ; Palbociclib (Primary) ; Pertuzumab (Primary) ; Sapanisertib (Primary) ; Sunitinib (Primary) ; Taselisib (Primary) ; Trametinib (Primary) ; Trastuzumab emtansine (Primary) ; Ulixertinib (Primary) ; Vismodegib (Primary)
  • Indications Adenocarcinoma; Adenoid cystic carcinoma; Advanced breast cancer; Anal cancer; Bladder cancer; Carcinoma; Cervical cancer; Cholangiocarcinoma; CNS cancer; Colorectal cancer; Endometrial cancer; Gastrointestinal cancer; Glioblastoma; Gliosarcoma; Haemangiosarcoma; Head and neck cancer; Leiomyosarcoma; Liver cancer; Lung cancer; Lymphoma; Malignant melanoma; Mesothelioma; Multiple myeloma; Non-small cell lung cancer; Oesophageal cancer; Osteosarcoma; Ovarian cancer; Pancreatic cancer; Perivascular epithelioid cell tumours; Prostate cancer; Renal cell carcinoma; Salivary gland cancer; Sarcoma; Solid tumours; Squamous cell cancer; Thyroid cancer; Triple negative breast cancer; Urogenital cancer; Uterine cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms MATCH; NCI-MATCH; NCI-MATCH ECOG-ACRIN Trial (EAY131)

    • Most Recent Events

    • 04 Jun 2024 Results(n=200) reporting the molecular profiles of ctDNA from a subset of the NCI-MATCH screened patients with gynecologic cancers, presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 06 Jun 2023 Results of an analysis assessing molecular profiling of ctDNA from patients enrolled in this trial for treatment with mTOR1/2 inhibitor sapanisertib (arm M) and the Hedgehog pathway inhibitor vismodegib (arm T) presented at the 59th Annual Meeting of the American Society of Clinical Oncology
    • 06 Jun 2023 Results of subprotocols C1 (n=44) and C2 (n=20) assessing efficacy of crizotinib in patients with MET amplification and MET exon 14 deletion, presented at the 59th Annual Meeting of the American Society of Clinical Oncology.

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