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A Phase IIa, Open-Label, Multi-Center, Multi-Cohort, Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) With a Sequential Switch to a 2nd IMT (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (Stage IIIB-IV)

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Trial Profile

A Phase IIa, Open-Label, Multi-Center, Multi-Cohort, Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) With a Sequential Switch to a 2nd IMT (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (Stage IIIB-IV)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 05 Aug 2019

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At a glance

  • Drugs Docetaxel (Primary) ; Durvalumab (Primary) ; Gefitinib (Primary) ; Osimertinib (Primary) ; Selumetinib (Primary) ; Tremelimumab (Primary)
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Sponsors AstraZeneca

    • Most Recent Events

    • 22 Jul 2016 Status changed from active, no longer recruiting to completed.
    • 11 Jan 2016 Planned End Date changed from 1 Nov 2017 to 1 Aug 2016 as per ClinicalTrials.gov record.
    • 30 Mar 2015 Status changed from recruiting to active, no longer recruiting, as per ClinicalTrials.gov record.
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